Heparin Bonding Reduces Thrombogenicity of Pulmonary-Artery Catheters

作者: Paul F. Hoar , Ross M. Wilson , Dennis T. Mangano , G. James Avery , Robert J. Szarnicki

DOI: 10.1056/NEJM198110223051707

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摘要: THROMBI form on the surface of pulmonary-artery catheters soon after these devices are inserted into central circulation.1 Although complications attributable to such thrombi do not occur frequently, their consequences can be serious: pulmonary embolism,2 , 3 occlusive vascular thromboses,4 5 and thrombotic endocardial vegetations.6 7 Catheter thrombogenicity is believed involve an interaction blood with physicochemical textural properties catheter's surface.8 9 10 11 Therefore, treatment catheter by chemical processes that reduce thrombus formation in vitro models may decrease patients.12 One method bond heparin chemically12 13 polymer plastics used . . .

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