Occupational and environmental levels of mutagenic PAHs and respirable particulate matter associated with diesel exhaust in Santiago, Chile.
作者： Lionel Gil , Victor Martínez , Romina Riquelme , Patricia Ancic , Ginés González
DOI: 10.1097/01.JOM.0000085891.74340.5A
关键词:
摘要: This work studied the mutagenic potential and polycyclic aromatic hydrocarbon (PAH) levels onto PM 10 collected in diesel revision plants, an urban area as well a rural Santiago, Chile. The average emission plants during working hours (there is no occupational Chilean standard) were significantly higher than atmospheric standard highly with high PAHs levels. Additionally, we evaluated contribution of CYP1A1 GSTMI polymorphisms on 1-OH-pyrene urinary diesel-exposed workers carrying CYP1A1*2A allele showed 1-OH-P subjects from same genotype. found individuals combined null kind information might be relevant to establish prevention, protection, mitigation actions protect public health.
sci-hub.se 参考文章(38)
Isabelle Stücker, Michele Jacquet, I. de Waziers, S. Cénée, Ph. Beaune, P. Kremers, D. Hémon, Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population. Pharmacogenetics. ,vol. 10, pp. 617- 627 ,(2000) , 10.1097/00008571-200010000-00005
B Ostro, G S Eskeland, C Aranda, J M Sanchez, Air pollution and mortality: results from a study of Santiago, Chile. Journal of Exposure Science and Environmental Epidemiology. ,vol. 6, pp. 97- 114 ,(1996)
Christine B. Ambrosone, Jo L. Freudenheim, Rosemary Laughlin, Takuma Nemoto, Anita Harrington, Peter G. Shields, Saxon Graham, John E. Vena, James R. Marshall, John R. Brasure, Tracey D. Ford, Arthur M. Michalek, Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk. Cancer Research. ,vol. 55, pp. 3483- 3485 ,(1995)
Robert F Smith, Hugh M Mather, Gordon A Ellard, Assessment of simple colorimetric procedures to determine smoking status of diabetic subjects Clinical Chemistry. ,vol. 44, pp. 275- 280 ,(1998) , 10.1093/CLINCHEM/44.2.275
M. Jacquet, V. Lambert, E. Baudoux, M. Muller, P. Kremers, J. Gielen, Correlation between P450 CYP1A1 inducibility, MspI genotype and lung cancer incidence. European Journal of Cancer. ,vol. 32, pp. 1701- 1706 ,(1996) , 10.1016/0959-8049(96)00172-4
L Quiñones, F Berthou, N Varela, B Simon, L Gil, D Lucas, Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations Cancer Letters. ,vol. 141, pp. 167- 171 ,(1999) , 10.1016/S0304-3835(99)00099-3
S.-I. Hayashi, J. Watanabe, K. Nakachi, K. Kawajin, PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene Nucleic Acids Research. ,vol. 19, pp. 4797- 4797 ,(1991) , 10.1093/NAR/19.17.4797
Bruce N. Ames, Joyce McCann, Edith Yamasaki, Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test Mutation Research. ,vol. 31, pp. 347- 364 ,(1975) , 10.1016/0165-1161(75)90046-1
Kaname Kawajiri, Kei Nakachi, Kazue Imai, Akira Yoshii, Nahomi Shinoda, Junko Watanabe, Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene FEBS Letters. ,vol. 263, pp. 131- 133 ,(1990) , 10.1016/0014-5793(90)80721-T
Herbert S. Rosenkranz, Mutagenic nitroarenes, diesel emissions, particulate-induced mutations and cancer: an essay on cancer-causation by a moving target. Mutation Research\/genetic Toxicology. ,vol. 367, pp. 65- 72 ,(1996) , 10.1016/0165-1218(95)00066-6