Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations
作者： L Quiñones , F Berthou , N Varela , B Simon , L Gil
DOI: 10.1016/S0304-3835(99)00099-3
关键词:
摘要: Many investigators have reported an association between genetic polymorphisms of cytochromes P-450 CYP2E1, CYP1A1 or glutathione S-transferase Mu (GSTM1) and susceptibility to lung cancer. However, pronounced interethnic variations been described in the frequencies these polymorphisms, especially Asians Caucasians. The present study was set up establish CYP2E1 (c1, c2 C, D), (m1, m2 Ile, Val) GSTM1 (null) allelic Chileans (n=96) who are admixture Native Americans Caucasians (Spaniards). rare allele were found be 0.15 (c2), 0.21 (C), 0.23 (m2), 0.32 (Val) ('null' genotype). These values significantly higher than those except for 'null' genotype suggest differences cancer both populations.
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