Photothermal-modulated drug delivery and magnetic relaxation based on collagen/poly(γ-glutamic acid) hydrogel

摘要: Injectable and stimuli-responsive hydrogels have attracted attention in molecular imaging drug delivery because encapsulated diagnostic or therapeutic components the hydrogel can be used to image change microenvironment of injection site by controlling various stimuli such as enzymes, temperature, pH, photonic energy. In this study, we developed a novel injectable photoresponsive composite composed anticancer drugs, contrast agents, bio-derived collagen, multifaceted anionic polypeptide, poly (γ-glutamic acid) (γ-PGA). By introduction γ-PGA, intrinsic temperature-dependent phase transition behavior collagen was modified low viscous sol state at room temperature nonflowing gel around body temperature. The collagen/γ-PGA also evaluated after loading near-infrared (NIR) fluorophore, indocyanine green (ICG), which could transform absorbed NIR energy into thermal taking advantage abundant carboxylate groups cationic-charged doxorubicin (Dox) hydrophobic MnFe2O4 magnetic nanoparticles were incorporated successfully hydrogels. illumination light on collagen/γ-PGA/Dox/ICG/MnFe2O4 hydrogels, release kinetics Dox relaxation modulated. experimental results suggest that NIR-responsive study theranostic platform probes components.