The effect of taxol on living eggs ofXenopus laevis
作者： Steven R. Heidemann , Peter T. Gallas
DOI: 10.1016/0012-1606(80)90421-2
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摘要: Taxol is an antitumor compound which promotes assembly of microtubules in vitro . We report here that taxol the initiation microtubule when injected into living eggs Xenopus laevis In unfertilized injections more than 0.50 ng induce formation aster-like structures within 1 hr. This accompanied by abnormal cleavage furrows. fertilized arrests division blastomere two- and four-cell embryos. Such arrested blastomeres contain asters at higher doses. The arrest caused injection was similar to cytostatic activity extracts from
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