Relationships between fasting plasma insulin, anthropometrics, and metabolic parameters in a very old healthy population

摘要: Abstract Several studies have shown that insulin resistance and hyperinsulinemia are associated with many metabolic disorders predisposing to coronary heart disease (CHD). This syndrome has been termed X. However, it is not completely known whether these relationships still present in the elderly, or other factors such as age, gender, body fat distribution modulate them. Therefore, we investigated relationship between fasting plasma insulin, total regional adiposity, glucose lipids, plasminogen activator inhibitor-1 (PAI-1), fibrinogen, coagulation factor VII a sample of 100 healthy free-living octogenarians-nonagenarians (52 men 48 women) who were disability-free according Katz index. By univariate analysis, correlated positively all anthropometric measures except waist hip ratio (WHR) women. There was positive correlation ( r = .40, P .21, .33, −.22 −.24, respectively, R 2 .14), while gender best predictors HDL-C variance .17). Furthermore, only variable independently related PAI-1 .12). Our findings support existence even very old age by showing high levels various hemostatic disorders.