Evaluation of a multiplex immunoassay for bovine respiratory syncytial virus and bovine coronavirus antibodies in bulk tank milk against two indirect ELISAs using latent class analysis
作者： Ingrid Toftaker , Nils Toft , Maria Stokstad , Liv Sølverød , Gordon Harkiss
DOI: 10.1016/J.PREVETMED.2018.03.008
关键词:
摘要: Bovine respiratory syncytial virus (BRSV) and bovine coronavirus (BCV) are responsible for disease diarrhea in cattle worldwide. The Norwegian control program against these infections is based on herd-level diagnosis using a new multiplex immunoassay. objective of this study was to estimate sensitivity specificity across different cut-off values the MVD-Enferplex BCV/BRSV multiplex, by comparing them commercially available ELISA, SVANOVIR® BCV-Ab BRSV-Ab, respectively. We analyzed bulk tank milk samples from 360 herds low- high-prevalence area. As none tests were considered perfect, estimation test characteristics performed Bayesian latent class models. At manufacturers' recommended values, median BRSV ELISA 94.4 [89.8-98.7 95% Posterior Credibility Interval (PCI)] 99.8 [98.7-100 PCI], 90.6 [85.5-94.4 but only 57.4 [50.5-64.4 PCI] ELISA. However, increasing increased without compromising sensitivity. For BCV we found that one three antigens included test, increased, concurrent loss resulted 99.9 [99.3-100 93.7 [88.8-97.8 99.5 [98.1-100 99.6 [97.6-100
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