Empirical evidence of design-related bias in studies of diagnostic tests
作者： Jeroen G Lijmer , Ben Willem Mol , Siem Heisterkamp , Gouke J Bonsel , Martin H Prins
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摘要: ContextThe literature contains a large number of potential biases in the evaluation of diagnostic tests. Strict application of appropriate methodological criteria would invalidate the clinical application of most study results. ObjectiveTo empirically determine the quantitative effect of study design shortcomings on estimates of diagnostic accuracy. Design and SettingObservational study of the methodological features of 184 original studies evaluating 218 diagnostic tests. Meta-analyses on diagnostic tests were identified through a systematic …
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