Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy men.

摘要: Near-infrared spectroscopy (NIRS) has the potential for clinical application in neuropsychiatry because it enables non-invasive and convenient measurement of hemodynamic response to cognitive activation. Using 24-channel NIRS 12 healthy men, we examined replicability oxy- deoxy-hemoglobin concentration ([oxyHb], [deoxyHb]) changes prefrontal cortex during category fluency task over four repeated sessions (each 1-week apart). Multiple methods were employed evaluate magnitude, location, time course signals [deoxyHb]). Task performances did not differ significantly across sessions, nor they correlated with signals. Repeated measures ANOVA variance component analysis indicated high magnitude both measures, whereas effect sizes between-session differences [oxyHb] negligible. The number spatial location activated channels sufficiently replicable except that across-session overlap was weak [deoxyHb]. activation acceptably measures. Taken together, these findings suggest there is considerable multiple-time measurements hemodynamics men. Further studies using different conditions or assessing sensitivity longitudinal following interventions are necessary.