Verbal fluency as a prefrontal activation probe: a validation study using 99mTc-ECD brain SPET
作者： Kurt Audenaert , Boudewijn Brans , Koen Van Laere , Philippe Lahorte , Jan Versijpt
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摘要: This study aimed to investigate the feasibility of brain single-photon emission tomography (SPET) in letter and category fluency paradigm Controlled Oral Word Association (COWA) test healthy volunteers. Two groups each comprising ten right-handed volunteers were injected twice with 370 MBq technetium-99m ethyl cysteinate dimer following a split-dose (resting activation condition). Statistical parametric mapping (SPM96) was used determine voxelwise significant changes. The had differential pattern. posterior part left inferior prefrontal cortex (LIPC) activated both paradigms, task having an extra anterior LIPC. In task, but not right found. These findings confirm large extent results previous functional magnetic resonance imaging positron studies semantic phonological paradigms. choice validity various methodological characteristics experimental design leading these are critically discussed. It is concluded that SPET under standard neuropsychological conditions technically practically feasible.
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P D Acton, K J Friston, Statistical parametric mapping in functional neuroimaging: beyond PET and fMRI activation studies European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 25, pp. 663- 667 ,(1998)
Nancy Ann Pachana, Kyle Brauer Boone, Bruce L. Miller, Jeffrey L. Cummings, Nancy Berman, Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia Journal of The International Neuropsychological Society. ,vol. 2, pp. 505- 510 ,(1996) , 10.1017/S1355617700001673
Anthony D. Wagner, John E. Desmond, Jonathan B. Demb, Gary H. Glover, John D. E. Gabrieli, Semantic Repetition Priming for Verbal and Pictorial Knowledge: A Functional MRI Study of Left Inferior Prefrontal Cortex Journal of Cognitive Neuroscience. ,vol. 9, pp. 714- 726 ,(1997) , 10.1162/JOCN.1997.9.6.714
Michael J. Boivin, Bruno Giordani, Stanley Berent, David A. Amato, Shirley Lehtinen, Robert A. Koeppe, Henry A. Buchtel, Norman L. Foster, David E. Kuhl, Verbal fluency and positron emission tomographic mapping of regional cerebral glucose metabolism. Cortex. ,vol. 28, pp. 231- 239 ,(1992) , 10.1016/S0010-9452(13)80051-2
Allen Y Tien, Thomas E Schlaepfer, William Orr, Godfrey D Pearlson, SPECT brain blood flow changes with continuous ligand infusion during previously learned WCST performance. Psychiatry Research-neuroimaging. ,vol. 82, pp. 47- 52 ,(1998) , 10.1016/S0925-4927(98)00003-1
DIANE SWICK, ROBERT T. KNIGHT, Is prefrontal cortex involved in cued recall? A neuropsychological test of PET findings. Neuropsychologia. ,vol. 34, pp. 1019- 1028 ,(1996) , 10.1016/0028-3932(96)00011-5
J. D. E. Gabrieli, R. A. Poldrack, J. E. Desmond, The role of left prefrontal cortex in language and memory Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 906- 913 ,(1998) , 10.1073/PNAS.95.3.906
D. Klein, B. Milner, R. J. Zatorre, E. Meyer, A. C. Evans, The Neural Substrates Underlying Word Generation: A Bilingual Functional- Imaging Study Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 2899- 2903 ,(1995) , 10.1073/PNAS.92.7.2899
Julie A. Fiez, Phonology, semantics, and the role of the left inferior prefrontal cortex Human Brain Mapping. ,vol. 5, pp. 79- 83 ,(1997) , 10.1002/(SICI)1097-0193(1997)5:2<79::AID-HBM1>3.0.CO;2-J
D Cardebat, JF Demonet, G Viallard, S Faure, M Puel, P Celsis, None, Brain functional profiles in formal and semantic fluency tasks: a SPECT study in normals. Brain and Language. ,vol. 52, pp. 305- 313 ,(1996) , 10.1006/BRLN.1996.0013