Agmatine Improves Spatial Memory Consolidation: The Role of Nitric Oxide
作者： Golnaz Yadollahi Khales , Atefeh Khajeh , Maryam Moosavi
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摘要: Objective: The existence of agmatine in the hippocampus suggests a role memory formation. Endogenous increases after training hippocampus, howbeit effect exogenous on is not consistent yet. This work was aimed to assess differential systemic spatial consolidation and retrieval. Additionally L-NAME used if nitric oxide involved agmatine. Methods: Male Sprague-Dawley rats (250-350 g) were trained water maze single session. After 24 h animals examined probe trial which consisted without platform. To (40 mg/kg) it administered immediately its retrieval injected 30 min before trial. In order evaluate involvement oxide, (3 co-administered with Results: Post-training injection (to phase) improved performance test, while pre-probe administration had no effect. prevented improving phase memory. Conclusion: Agmatine improves has Nitric
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