摘要: Personalized medicine for cancer entails tailoring therapy each patient based on unique features of the patient's tumor; physiologic, molecular, genetic and epigenetic. Our ability to molecularly characterize tumor cells has increased dramatically shown that there are significant differences between samples from patients with same type. Given this extensive variability in mutations pathways driving tumors patients, seeking a single bullet is an unrealistic approach achieving cure. In glioblastoma multiforme (GBM), most common adult brain tumor, inter-tumoral heterogeneity further complicated by intra-tumoral within tumor. This suggests personalized work GBMs, pharmacologic agents would not only be tailored target but also clonal diversity review, we provide historical perspective clinical trials cancer. We discuss current state molecular biology immunology strategies therapies multiforme.
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