摘要: MicroRNAs (miRNAs) are short, endogenous RNAs that have essential roles in regulating gene expression through the disruption of target genes. The miRNA-induced suppression can occur Argonaute-mediated cleavage mRNAs or by translational inhibition. System-wide studies underscored integral role miRNAs play genes within bone marrow stromal cells. miRNA has been shown to enhance inhibit cell differentiation and activity, elucidating targets cells revealed novel regulations during normal development. Importantly, multiple misexpression mediates progression bone-related pathologies, including osteopetrosis osteoporosis, as well development osteosarcoma. Furthermore, recent detailed capacity for influence metastasis from a number primary carcinomas. Taken together, these findings reveal significant clinical potential regulate homeostasis, mediate pathologies.
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sci-hub.se 参考文章(109)
Giulia Ottaviani, Norman Jaffe, The Epidemiology of Osteosarcoma Cancer treatment and research. ,vol. 152, pp. 3- 13 ,(2009) , 10.1007/978-1-4419-0284-9_1
Pediatric and adolescent osteosarcoma Springer. pp. 573- 575 ,(2010) , 10.1007/978-1-4419-0284-9
Maria Teresa Di Martino, Annamaria Gullà, Maria Eugenia Gallo Cantafio, Marta Lionetti, Emanuela Leone, Nicola Amodio, Pietro Hiram Guzzi, Umberto Foresta, Francesco Conforti, Mario Cannataro, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone, In Vitro and in Vivo Anti-tumor Activity of miR-221/222 inhibitors in multiple myeloma Oncotarget. ,vol. 4, pp. 242- 255 ,(2013) , 10.18632/ONCOTARGET.820
Feng-Sheng Wang, Pei-Chin Chung, Chung-Liang Lin, Ming-Wen Chen, Huei-Jin Ke, Yu-Hsuan Chang, Yu-Shan Chen, Shin-Long Wu, Jih-Yang Ko, MicroRNA‐29a Protects Against Glucocorticoid‐Induced Bone Loss and Fragility in Rats by Orchestrating Bone Acquisition and Resorption Arthritis & Rheumatism. ,vol. 65, pp. 1530- 1540 ,(2013) , 10.1002/ART.37948
Chao Chen, Peng Cheng, Hui Xie, Hou-De Zhou, Xian-Ping Wu, Er-Yuan Liao, Xiang-Hang Luo, MiR-503 regulates osteoclastogenesis via targeting RANK. Journal of Bone and Mineral Research. ,vol. 29, pp. 338- 347 ,(2014) , 10.1002/JBMR.2032
Jun Dong, Xingang Cui, Zhensong Jiang, Jianmin Sun, MicroRNA‐23a modulates tumor necrosis factor‐alpha‐induced osteoblasts apoptosis by directly targeting fas Journal of Cellular Biochemistry. ,vol. 114, pp. 2738- 2745 ,(2013) , 10.1002/JCB.24622
S. Vimalraj, Nicola C. Partridge, N. Selvamurugan, A positive role of microRNA-15b on regulation of osteoblast differentiation. Journal of Cellular Physiology. ,vol. 229, pp. 1236- 1244 ,(2014) , 10.1002/JCP.24557
Toshifumi Sugatani, Blake E Hildreth III, Ramiro E Toribio, Hartmut H Malluche, Keith A Hruska, Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity. Journal of Cellular Biochemistry. ,vol. 115, pp. 1043- 1047 ,(2014) , 10.1002/JCB.24759
Nicola Amodio, Marzia Leotta, Dina Bellizzi, Maria Teresa Di Martino, Patrizia D’Aquila, Marta Lionetti, Fernanda Fabiani, Emanuela Leone, Anna Maria Gullà, Giuseppe Passarino, Michele Caraglia, Massimo Negrini, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone, DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma Oncotarget. ,vol. 3, pp. 1246- 1258 ,(2012) , 10.18632/ONCOTARGET.675
Li Chen, Kim HolmstrØm, Weimin Qiu, Nicholas Ditzel, Kaikai Shi, Lea Hokland, Moustapha Kassem, MicroRNA-34a inhibits osteoblast differentiation and in vivo bone formation of human stromal stem cells. Stem Cells. ,vol. 32, pp. 902- 912 ,(2014) , 10.1002/STEM.1615