Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patient with acute leukemia via inhibiting the activation of PI3K/Akt and ERK1/2 pathways
作者： Jieping Li , Dongfeng Zeng , Peiyan Kong , Cheng Chang , Jiali Li
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摘要: Aberrant angiogenesis is essential to the development and progression of leukemia. Ginsenoside Rg3 has been commonly used in anti-angiogenic therapy solid tumors. This study aimed investigate effects patients with acute Bone marrow stromal cells derived from leukemia were treated expression vascular endothelial growth factor (VEGF) hypoxia-inducible 1α (HIF-1α) was detected by RT-PCR western blot analysis. The results showed that inhibited VEGF HIF-1α at both mRNA protein levels bone cells. In addition, treatment led reduced serum Mechanistically, we demonstrated downregulated phosphorylation Akt ERK1/2 BMSCs. conclusion, exhibits anti-leukemia effect part due its activity via inhibiting PI3K/Akt pathways, which act regulate VEGF.
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