CCl4 induces tissue-type plasminogen activator in rat brain; protective effects of oregano, rosemary or vitamin E.

摘要: The high metabolic rate and relatively low antioxidant defenses of the lipid-rich brain tissue render it highly susceptible to reactive oxygen species (ROS) oxidative stress, whereas implication ROS in pathogenesis several diseases central nervous system is well-established. plasminogen activator (PA) a key modulator extracellular proteolysis, matrix remodeling neuronal cell signaling has been implicated these diseases. This study evaluates role tissue-type PA (t-PA) stress protective dietary antioxidants rat brain. We used CCl4 experimental model ROS-induced lipid peroxidation evaluated effect oregano, rosemary or vitamin E. CCl4-treated Wistar rats exhibited elevated t-PA activity, which was decreased upon long-term administration inhibitor-1 (PAI-1) activity also slightly by CCl4, but this increase not affected antioxidants. hypothesize that CCl4-induced indicates proteolytic may be linked death damage. Vitamin E present oregano are effective inhibiting elevation can considered as potential protection against