Neuroprotective effects of α-tocotrienol on kainic acid-induced neurotoxicity in organotypic hippocampal slice cultures.
作者： Na Jung , Kyung Lee , Ran Won , Bae Lee
关键词:
摘要: Vitamin E, such as alpha-tocopherol (ATPH) and alpha-tocotrienol (ATTN), is a chain-breaking antioxidant that prevents the chain propagation step during lipid peroxidation. In present study, we investigated effects of ATTN on KA-induced neuronal death using organotypic hippocampal slice culture (OHSC) compared neuroprotective ATPH. After 15 h KA (5 µM) treatment, delayed was detected in CA3 region reactive oxygen species (ROS) formation peroxidation were also increased. Both co-treatment post-treatment ATPH (100 or significantly increased cell survival reduced number TUNEL-positive cells region. Increased dichlorofluorescein (DCF) fluorescence levels thiobarbiturate substances (TBARS) decreased by treatment. These data suggest treatment have protective OHSC. tended to be more effective than even though there no significant difference between post-treatment.
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