Tumor markers in the human ovary and its neoplasms. A comparative immunohistochemical study.

摘要: The incidence and histologic characteristics of the expression placental alkaline phosphatase (PLAP) in ovarian tumors was compared with that five other tumor antigens. Three monoclonal antibodies were used for specific localization PLAP. PLAP present some sex cord cells 13-16-week fetal ovary, probably germ cells. In normal ovaries, all antigens except carcinoembryonic antigen (CEA) frequently found inclusion cysts; germinal epithelium positive only cancer 125 (CA 125). frequency extent nonmucinous carcinomas higher than observed CA 19-9 CEA, but lower human milk fat globule antigen. Serous had highest expression, followed by endometrioid poorly differentiated adenocarcinomas, tumors. predominantly membranous; its distribution general heterogeneous. Different to gave different staining intensities tumors, patterns always qualitatively identical.