MicroRNA-216b regulates cell proliferation, invasion and cycle progression via interaction with cyclin T2 in gastric cancer.
作者： Xi Chen , Lei Zhang , Qingjie Song , Zhong Chen
DOI: 10.1097/CAD.0000000000000915
关键词:
摘要: Gastric cancer has become the second most common malignant tumor in world, revealing molecular mechanism of gastric development is essential for treatment and improvement prognosis. Recent studies have shown that microRNAs may play a carcinogenic or tumor-suppressive role many types cancer. It been detected miR-216b down-regulated types, indicating can be used as prognostic marker these particular However, effect on remains unclear. In present study, miR-216 was observed to significantly tissues compared normal tissues, level various cell lines decreased. addition, overexpression inhibits proliferation, migration, invasion, cycle apoptosis cells. We further verified inhibitory proliferation invasion cells mediated by cyclin T2. Overexpression T2 reverse anti-cancer mimics. The results enriched progression
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