Polyacrylate-Based Delivery System for Self-adjuvanting Anticancer Peptide Vaccine
作者： Tzu-Yu Liu , Waleed M. Hussein , Ashwini Kumar Giddam , Zhongfan Jia , Jennifer M. Reiman
DOI: 10.1021/JM501514H
关键词:
摘要: Vaccination can provide a safe alternative to chemotherapy by using the body’s natural defense mechanisms create potent immune response against tumor cells. Peptide-based therapeutic vaccines human papillomavirus (HPV)-related cancers are usually designed elicit cytotoxic T cell responses targeting HPV-16 E7 oncoprotein. However, peptides alone lack immunogenicity, and an additional adjuvant or external delivery system is required. In this study, we developed new polymer–peptide conjugates efficient self-adjuvanting for peptide-based vaccines. These reduced growth eradicated E7-positive TC-1 tumors in mice after “single shot” immunization, without help from adjuvant. The had significantly higher anticancer efficacy than antigen formulated with commercial Furthermore, were promptly taken up presenting cells, including dendritic cells ma...
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