A microfluidic paper-based analytical device for rapid quantification of particulate chromium

摘要: Abstract Occupational exposure to Cr is concerning because of its myriad health effects. Assessing chromium also cost and resource intensive the analysis typically uses sophisticated instrumental techniques like inductively coupled plasma-mass spectrometry (ICP-MS). Here, we report a novel, simple, inexpensive microfluidic paper-based analytical device (μPAD) for measuring total in airborne particulate matter. In μPAD, tetravalent cerium (Ce(IV)) was used pretreatment zone oxidize all soluble Cr(VI). After elution detection zone, Cr(VI) reacts with 1,5-diphenylcarbazide (1,5-DPC) forming 1,5-diphenylcarbazone (DPCO) Cr(III). The resulting Cr(III) forms distinct purple colored complex DPCO. As proof-of-principle, matter (PM) collected on sample filter analyzed μPAD quantify mass Cr. A log-linear working range (0.23–3.75 μg; r 2  = 0.998) between color intensity obtained limit 0.12 μg. For validation, certified reference containing multiple competing metals analyzed. Quantitative agreement known levels measured using μPAD.