Vitamins C and E and the risks of preeclampsia and perinatal complications
作者： Alice R. Rumbold , Caroline A. Crowther , Ross R. Haslam , Gustaaf A. Dekker , Jeffrey S. Robinson
DOI: 10.1056/NEJMOA054186
关键词:
摘要: Background Supplementation with antioxidant vitamins has been proposed to reduce the risk of preeclampsia and perinatal complications, but effects this intervention are uncertain. Methods We conducted a multicenter, randomized trial nulliparous women between 14 22 weeks gestation. Women were assigned daily supplementation 1000 mg vitamin C 400 IU E or placebo (microcrystalline cellulose) until delivery. Primary outcomes risks maternal preeclampsia, death serious in infants (on basis definitions used by Australian New Zealand Neonatal Network), delivering an infant whose birth weight was below 10th percentile for gestational age. Results Of 1877 enrolled study, 935 randomly group 942 group. Baseline characteristics two groups similar. There no significant differences ...
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