Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide

作者: Mohit Atul Kothare , Hon-Wah Man

DOI:

关键词:

摘要: Provided herein are isotopologues of Compound A, which enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods using compounds also provided. Embodiments provided encompass A pharmaceutically acceptable salts, stereoisomers, tautomers, solid forms, polymorphs, hydrates, clathrates, solvates thereof.

参考文章(94)
Jason Boer, Kirk R Henne, Michael B Fisher, The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism. Current Opinion in Drug Discovery & Development. ,vol. 9, pp. 101- ,(2006)
Helen Maureen Mcguire, Suzanne Stokes, Daemian David Dussault, Holia Hatoum-Mokdad, Georgine Ioannidis, Ann Boriack-Sjodin, John Irvin Manchester, David Charles Mckinney, Daniel Robert Carcanague, Kenneth Gregory Hull, Heterocyclic derivatives and methods of use thereof ,(2009)
Steven Richard Brunette, Matt Aaron Tschantz, Jin Mi Kim, Rene Marc Lemieux, Pyrimidine Derivatives Useful as Inhibitors of Pkc-Theta ,(2006)
David A. Mareska, Darren M. Harvey, Martha E. Rodriguez, Robert D. Groneberg, Michael O'sullivan, Jeremy J. Hans, Piperidine-containing compounds and use thereof ,(2010)
Wolin Huang, Jack W. Rose, Mukund Mehrotra, Qing Xu, Shawn M. Bauer, Anjali Pandey, Yonghong Song, Inhibitors of jak ,(2010)
Koichiro Mukoyoshi, Jun Maeda, Akira Tanaka, Yuji Takasuna, Shinya Nagashima, Shigeki Kunikawa, Noboru Chida, 2,4-diaminopyrimidine compound ,(2009)
Takeshi Terasawa, Shinji Itoh, Shinji Shigenaga, Noe Ishii, Hideyuki Watanabe, Satoshi Kubo, Jun Maeda, Heterocyclic carboxamide compounds ,(2009)
Ankush Argade, Sacha J. Holland, Jeffrey Clough, Holger Keim, Donald Payan, Rajinder Singh, Catherine Sylvain, Alexander B. Rossi, Susan Molineaux, Somasekhar Bhamidipati, Hui Li, 5-Fluoro-4N-phenyl-4-pyrimidineamine compounds ,(2004)