Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
作者： Marie Georges Beauchamps , Hon-Wah Man , Ying Li , Daozhong Zou , Lianfeng Huang
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摘要: Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
lens.org 参考文章(118)
Sara N Vallerie, Gökhan S Hotamisligil, The Role of JNK Proteins in Metabolism Science Translational Medicine. ,vol. 2, ,(2010) , 10.1126/SCITRANSLMED.3001007
Harmeet Malhi, Steven F. Bronk, Nathan W. Werneburg, Gregory J. Gores, Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis Journal of Biological Chemistry. ,vol. 281, pp. 12093- 12101 ,(2006) , 10.1074/JBC.M510660200
Robert F. Schwabe, Hiroshi Uchinami, Ting Qian, Brydon L. Bennett, John J. Lemasters, David A. Brenner, Differential requirement for c-Jun NH2-terminal kinase in TNFα- and Fas-mediated apoptosis in hepatocytes The FASEB Journal. ,vol. 18, pp. 720- 722 ,(2004) , 10.1096/FJ.03-0771FJE
Gary R Fanger, Pär Gerwins, Christian Widmann, Matthew B Jarpe, Gary L Johnson, MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? Current Opinion in Genetics & Development. ,vol. 7, pp. 67- 74 ,(1997) , 10.1016/S0959-437X(97)80111-6
Philip Cohen, Protein kinases--the major drug targets of the twenty-first century? Nature Reviews Drug Discovery. ,vol. 1, pp. 309- 315 ,(2002) , 10.1038/NRD773
Kunyong Yang, Wenshuo Lu, Bei Chen, Christian Cho-Hua Lee, Xiaohui He, Songchun Jiang, Thomas H. Marsilje, Pyrimidine derivatives as kinase inhibitors ,(2009)
Takahiro Miyake, Ichiro Umemura, Greg Chopiuk, Keiichi Masuya, Takanori Kanazawa, Nathanael Schiander Gray, Naoko Matsuura, Qiang Ding, Yongqin Wan, Qiong Zhang, Eiji Kawahara, Osamu Ohmori, Ruo Steensma, Donald Karanewsky, Carlos Garcia-Echeverria, Jiqing Jiang, 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders ,(2004)
Richland W. Tester, Shomir Ghosh, Arthur F. Kluge, Juswinder Singh, Russell C. Petter, 2,4-disubstituted pyrimidines useful as kinase inhibitors ,(2009)
Lynn C. Moscinski, Ariana B. Fisher, Bobbye J. Hill, Xiaotang Hu, Kenneth S. Zuckerman, Nikola I. Valkov, Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line. Cell Growth & Differentiation. ,vol. 11, pp. 191- 200 ,(2000)
Rajat Singh, Yongjun Wang, Youqing Xiang, Kathryn E. Tanaka, William A. Gaarde, Mark J. Czaja, Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology. ,vol. 49, pp. 87- 96 ,(2009) , 10.1002/HEP.22578