Differences in the stability of prostacyclin in human, rabbit and rat plasma
作者： K.E.H. El Tahir , K.I. Williams , D.J. Betteridge
DOI: 10.1016/S0262-1746(83)80001-8
关键词:
摘要: Prostacyclin (PGI2) is a potent vasodilator and inhibitor of platelet aggregation, however, its half-life in aqueous solutions at neutral or acid pH very short. In this study we have investigated the stability PGI2 plasma from different species demonstrated that anti-aggregatory hypotensive activity considerably prolonged human plasma. Interestingly was not maintained on incubation rat rabbit indicating stabilising factor may be confined to Whether such stabilisation prolongs circulation merits investigation.
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