Antithrombotic/anticoagulant and anticancer activities of selected medicinal plants from South Africa
作者： Nalise Low Ah Kee , Nandipha Mnonopi , Hajierah Davids , Ryno J Naudé , Carminita L Frost
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摘要: Nine plants available in the Eastern Cape Province of South Africa were tested for antithrombotic and/or anticoagulant activity. Organic (methanol) and aqueous (distilled water) extractions performed on various plant parts. The thrombin assay clotting time assays (thrombin-induced CaCl2-induced) utilised. Several extracts displayed activity, but most cases this was due to presence tannins. Only activity after tannin removal. Sutherlandia frutescens leaf extract with an IC50 value 2.17 mg/ml. Gloriosa superba Zantedeschia aethiopica properties by inhibiting thrombin-induced clotting, values 2.97 3.05 mg/ml, respectively. Leonotis leonurus root found decrease CaCl2-induced 50% at 8.88 A accompanied a fibrin formation preferable CaCl2- induced assay, since decreased may have role prevention cancer metastasis. As tannins contribute minimally effect L. leonurus, cytotoxicity potential species against five cell lines determined. organic yielded significant cytotoxity.
sci-hub.se 参考文章(17)
Ana Gibbs, Cleveland Green, V.M Doctor, Isolation and anticoagulant properties of polysaccharides of Typha Augustata and Daemonorops species. Thrombosis Research. ,vol. 32, pp. 97- 108 ,(1983) , 10.1016/0049-3848(83)90021-X
HITOSHI ISHIDA, TAKAYUKI UMINO, KUNIRO TSUJI, TAKUO KOSUGE, Studies on the antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. IX. On the antihemorrhagic principles in Typha lactifolia L. Chemical & Pharmaceutical Bulletin. ,vol. 36, pp. 4414- 4420 ,(1988) , 10.1248/CPB.36.4414
Gunilla B. Toth, Henrik Pavia, Removal of dissolved brown algal phlorotannins using insoluble polyvinylpolypyrrolidone (PVPP). Journal of Chemical Ecology. ,vol. 27, pp. 1899- 1910 ,(2001) , 10.1023/A:1010421128190
S.M. Harnett, V Oosthuizen, M. van de Venter, Anti-HIV activities of organic and aqueous extracts of Sutherlandia frutescens and Lobostemon trigonus. Journal of Ethnopharmacology. ,vol. 96, pp. 113- 119 ,(2005) , 10.1016/J.JEP.2004.08.038
Jorge Manuel Rosa de Medeiros, Manuelo Macedo, Joao P Contancia, Chi Nguyen, Glenn Cunningham, D.Howard Miles, Antithrombin activity of medicinal plants of the Azores. Journal of Ethnopharmacology. ,vol. 72, pp. 157- 165 ,(2000) , 10.1016/S0378-8741(00)00226-9
N. Gericke, B. van Oudtshoorn, B. E. van Wyk, Medicinal plants of South Africa ,(1997)
Andrew J. Gale, Stuart G. Gordon, Update on tumor cell procoagulant factors Acta Haematologica. ,vol. 106, pp. 25- 32 ,(2001) , 10.1159/000046586
Frederick R Rickles, Anna Falanga, Molecular Basis for the Relationship Between Thrombosis and Cancer Thrombosis Research. ,vol. 102, pp. V215- V224 ,(2001) , 10.1016/S0049-3848(01)00285-7
Jan A. Rob, Stig Tollefsen, Liv Helgeland, A Rapid and Highly Sensitive Chromogenic Microplate Assay for Quantification of Rat and Human Prothrombin Analytical Biochemistry. ,vol. 245, pp. 222- 225 ,(1997) , 10.1006/ABIO.1996.9976
Maimoona G. Chinwala, Min Gao, Jie Dai, Jun Shao, In Vitro Anticancer Activities of Leonurus heterophyllus Sweet (Chinese Motherwort Herb) Journal of Alternative and Complementary Medicine. ,vol. 9, pp. 511- 518 ,(2003) , 10.1089/107555303322284802