Osteoinductive demineralized cancellous bone

摘要: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the matrix are disclosed. The may be prepared by providing altering collagenous structure of bone. also compacting bone, example via mechanical compaction, grinding into a particulate, or treatment with chemical. Additives such as growth factors bioactive agents added to matrix. form an osteogenic osteoimplant. osteoimplant, when implanted in mammalian body, induce at locus implant full developmental cascade endochondral formation including vascularization, mineralization, marrow differentiation. used delivery device administer agents.