Interaction of epidermal growth factor (EGF) with cultured fibroblasts.
作者： Stanley Cohen , Graham Carpenter , Kenneth J. Lembach
DOI: 10.1016/B978-0-12-027308-9.50024-X
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摘要: Publisher Summary This chapter discusses the interaction of epidermal growth factor (EGF) with cultured fibroblasts. EGF is a single-chain polypeptide containing total 53 amino acid residues. All common acids are present except lysine, alanine, and phenylalanine. The molecule contains six half-cystine residues in disulfide bridges. antigenic sensitive to proteolytic digestion. It heat stable, nondialyzable, has an isoelectric point at pH 4.6. also complete sequence presents location three A direct stimulatory effect on epithelial cell proliferation vitro been demonstrated number organ culture systems. These include embryonic skin, cornea, mammary gland expiants. effects not species specific; expiants derived from chick, mouse, human responsive. stimulation cultures chick embryo skin dependent upon conditions, among which age presence dermal cells.
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