Both a calcium antagonist and ACE inhibitor reverse hypertrophy in hypertension but a calcium antagonist also depresses contractility.

摘要: The aim of this study was to compare the effects a calcium antagonist, nicardipine SR, with an angiotensin-converting enzyme (ACE) inhibitor, alacepril, on regression left ventricular hypertrophy (LVH) and function. Twenty patients LVH, aged 42–73 years, were treated SR or alacepril. Ten (40–80 mg) for 21 months, other 10 alacepril (25–100 18 months. All underwent echocardiography assess structure function before after treatment. After treatment, blood pressure decreased significantly from 176.0 ± 13.9/97.0 5.3 mmHg 140.0 14.0/77.4 7.2 168.2 22.3/99.0 5.5 138.4 12.5/85.2 9.7 mmHg, respectively (both p < 0.01), whereas heart rate did not change (73.8 14.6 beats/min vs. 69.9 13.5 71.6 65.8 8.1 beats/min, respectively). mass index 133.2 11.7 g/m2 114.4 15.7 137.1 14.8 99.3 23.0 0.01). fractional shortening, peak shortening rate, lengthening all improved each end-systolic wall stress/left volume index, as contractility, treatment but changed In conclusion, both similarly reduced LVH systolic diastolic However, alter nicardi-pine contractility.