Region-specific effects of STW 5 (Iberogast) and its components in gastric fundus, corpus and antrum.

摘要: Functional dyspepsia (FD) is a disorder that involves impaired gastric accommodation, antral hypomotility, and upper abdominal pain. The herbal drug STW 5 (Iberogast®) used to successfully treat FD patients. Here, we report in vitro data revealing the mode of action its individual extracts on motility. evoked relaxation proximal stomach but increased Both effects are myogenic. Angelica root, chamomile flower liquorice root mimicked inhibitory whereas greater celandine herb, Melissa leaf, caraway fruit bitter candy tuft motility stomach. All antrum comparable 5. We conclude differential distal motor activity not caused by solely spasmolytic or anti-spasmolytic components. It suggested target transduction mechanisms specifically expressed vs. present rationale for effect which result combined actions components reason excitatory may contribute symptom relief patients treated with (Iberogast®).