A Randomized, Clinical Trial of Preadmission Chlorhexidine Skin Preparation for Lower Extremity Total Joint Arthroplasty

摘要: Abstract Background Periprosthetic infections are devastating postoperative complications of total joint arthroplasty (TJA), with native skin flora commonly identified as causative organisms. We compared 2% chlorhexidine gluconate–impregnated cloths to standard-of-care antiseptic bathing in patients before TJA, evaluate periprosthetic infection risk at 1-year follow-up. Methods This was a prospective, randomized, controlled trial single institution undergoing hip or knee arthroplasty. Chlorhexidine-treated (275 arthroplasties) applied the night and morning admission. The cohort (279 bathed soap water preadmission. Patients were excluded according following: (1) unable comply study requirements, (2) pregnant, (3) .05). Results A lower rate found (0.4%) when cohorts (2.9%). odds ratio 8.15 (95% confidence interval = 1.01-65.6; P = .049) for cohort. No differences assessed factors between groups. severe adverse events observed. Conclusions Preoperative cloth use decreased infection. may be an appropriate protocol implement extremity TJA.