In vivo Antitumor Activities of Tumor Necrosis Factor-Alpha

作者: Michael A. Palladino

DOI: 10.1007/978-1-4612-4598-8_21

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摘要: The description of a tumor necrosis-inducing substance in the sera bearing mice and cytotoxic factor(s) cultures stimulated lymphoid cells triggered intense research efforts which resulted identification two distinct but related proteins, human necrosis factors (TNFs) -alpha -beta. tumors by TNF is only one biological activity high doses these immune system hormones. wide spectrum activities exhibited may be an indication their importance immunologic homeostatic phenomena.

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