Growth-inhibiting effect of intratumoral recombinant human tumor necrosis factor on an experimental model of primitive neuroectodermal tumor
作者： Jes�s Vaquero , Mercedes Zurita , Santiago Oya
DOI: 10.1007/BF01058454
关键词: Biology 、 Necrosis 、 Immunotherapy 、 Cytokine 、 Pathology 、 Primitive neuroectodermal tumor 、 Tumor necrosis factor alpha 、 Recombinant DNA 、 Neuroectodermal tumor 、 Central nervous system disease
摘要: The effect of intratumoral administration recombinant human tumor necrosis factor on an experimental model primitive neuroectodermal neoplasia was studied. A clear inhibition growth achieved by immunotherapy that consisted in intralesion injections 100 μg daily, the first three days each week, for a period four weeks. At this time, size 2.21 ± 0.66 cm2 (mean ±standard deviation) treated group, versus 7.62 0.43 control group. These data support previous studies influence development ethyl-nitrosourea-induced tumors, and suggest potential usefulness cytokine neoplasms.
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