Small volumes of enteral feedings normalise immune function in infants receiving parenteral nutrition

摘要: Abstract Background/Purpose: Parenteral nutrition (PN) is associated with a risk of septicaemia. This may be caused by impairment immune function related to PN. The authors investigated the effects addition enteral feedings PN on status human newborn infants. Methods: Ten surgical infants (age less than 6 months) requiring were studied in two consecutive phases: (A) after 31.1 ± 6.0 days (mean SEM) no feeding (total PN); and (B) 4.7 1.1 from small volumes Full blood count liver tests not significantly different between phases A B. control group (n = 9) receiving normal diet was also studied. Host bactericidal activity against coagulase-negative staphylococci (CNS) measured an vitro whole model. Bacterial killing 45-minute bacterial challenge using Miles-Misra technique. Tumour necrosis factor-α (TNF-α) enzyme-linked immunosorbent assay (ELISA) 2 hours challenge. Results: lowest level CNS (37.7 5.2%), observed patients total increased feeds (52.0 4.6%, P .006). Conclusions: These results indicate that introduction feed improve impaired abnormal cytokine response during implies stimulation gastrointestinal tract modulate neonates prevent infection.