Beclin 1 bridges autophagy, apoptosis and differentiation

摘要: Beclin 1 is a critical component in the class III PI3 kinase complex (PI3KC3) that induces formation of autophagosomes mammalian systems. Autophagic triggers upregulate 1, which turn binds to PI3KC3 or Bcl-XL form complexes 1-PI3KC3 1-Bcl-XL are physically and functionally independent from each other. Contrary previous observations binding Bcl-2 family members apoptotic antiautophagic, we found autophagic trigger-induced 1-binding antiapoptotic has no effect on autophagy, suggesting convertible role response autophagy stimuli. Both differentiation cascades require upregulation 1. While basal level does not cause differentiation, depletion cripples both capabilities, but activates apoptosis. These results demonstrate essential for ...