Aminergic Signaling Controls Ovarian Dormancy in Drosophila.

摘要: In response to adverse environmental conditions many organisms from nematodes mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense growth reproduction. Dormancy regulation has been studied in C. elegans several insects, but how neurosensory mechanisms act relay cues endocrine system order induce remains unclear. Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling Drosophila melanogaster. We find both serotonin dopamine adult ovarian dormancy, while downregulation their respective pathways cells tissues (insulin producing cells, fat body, corpus allatum) reduces dormancy. contrast, octopamine antagonizes Our findings our understanding cope with unfavorable environments illuminate some relevant pathways.