Variation in the frequency and type of sperm chromosomal abnormalities among normal men.
作者： Renee H. Martin , Alfred W. Rademaker , Kathy Hildebrand , Leslie Long-Simpson , Dianna Peterson
DOI: 10.1007/BF00272374
关键词:
摘要: The chromosomal constitution of 1582 human sperm from 30 normal men proven fertility was investigated after penetration hamster eggs. A minimum chromosome complements were analysed per donor so that the distribution and variation in frequency type abnormalities could be assessed. mean individual 10.4% (+/- 6.0%) with a range 0-24.7%. For numerical 4.7% 2.9%) 0-10% for structural 6.2% 0-23.1%. 95% confidence intervals an male 0-10.5% abnormalities, 0-18.2% 0-22.4% total abnormalities. There significant excess hypohaploid compared hyperhaploid complements. Since caused by technical artefact, conservative estimate aneuploidy obtained doubling sperm, yielding 2.4% aneuploidy. proportion X-bearing (53%) Y-bearing (47%) did not differ significantly. These results to other two large studies men.
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