摘要: The macrocyclic lactone rapamycin has an established place as immune suppressive agent in organ transplantation. However, more recently it been recognized inhibitor of pathways that may be activated during malignant transformation and tumor progression. Thus, increasing interest is being directed to this class antibiotic potential antitumor agents. Here we summarize the history, mechanism action, mechanisms resistance rapamycin.
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Erik S. Knudsen, Yan Chen, Jean Y J Wang, The RB/p107/p130 phosphorylation pathway is not inhibited in rapamycin-induced G1-prolongation of NIH3T3 cells. Oncogene. ,vol. 13, pp. 1765- 1771 ,(1996)
S G Zimmer, A DeBenedetti, J R Graff, Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis. Anticancer Research. ,vol. 20, pp. 1343- 1351 ,(2000)
Da-Qing Yang, Michael B. Kastan, Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nature Cell Biology. ,vol. 2, pp. 893- 898 ,(2000) , 10.1038/35046542
W.G. Morice, G Wiederrecht, G.J. Brunn, J.J. Siekierka, R.T. Abraham, Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. Journal of Biological Chemistry. ,vol. 268, pp. 22737- 22745 ,(1993) , 10.1016/S0021-9258(18)41589-X
Siniša Volarević, George Thomas, Role of S6 phosphorylation and S6 kinase in cell growth. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 65, pp. 101- 127 ,(2000) , 10.1016/S0079-6603(00)65003-1
W.G. Morice, G.J. Brunn, G. Wiederrecht, J.J. Siekierka, R.T. Abraham, Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes. Journal of Biological Chemistry. ,vol. 268, pp. 3734- 3738 ,(1993) , 10.1016/S0021-9258(18)53755-8
Michael B. Dilling, Glen S. Germain, Randall K. Johnson, David N. Shapiro, Peter Dias, Peter J. Houghton, Rapamycin Selectively Inhibits the Growth of Childhood Rhabdomyosarcoma Cells through Inhibition of Signaling via the Type I Insulin-like Growth Factor Receptor Cancer Research. ,vol. 54, pp. 903- 907 ,(1994)
Laszlo G. Radvanyi, Linda Z. Penn, Gordon B. Mills, Richard G. Miller, Yufang Shi, Andrea Frankel, Rapamycin Enhances Apoptosis and Increases Sensitivity to Cisplatin in Vitro Cancer Research. ,vol. 55, pp. 1982- 1988 ,(1995)
Anthoula Lazaris-Karatzas, Nahum Sonenberg, The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts. Molecular and Cellular Biology. ,vol. 12, pp. 1234- 1238 ,(1992) , 10.1128/MCB.12.3.1234
Enrique Rozengurt, Thomas Seufferlein, Rapamycin Inhibits Constitutive p70s6k Phosphorylation, Cell Proliferation, and Colony Formation in Small Cell Lung Cancer Cells Cancer Research. ,vol. 56, pp. 3895- 3897 ,(1996)