Role of S6 phosphorylation and S6 kinase in cell growth.

摘要: This article reviews our current knowledge of the role ribosomal protein S6 phosphorylation and kinase (S6K) signaling pathway in regulation cell growth proliferation. Although 40S was first described 25 years ago, it only recently has been implicated translational up-regulation mRNAs coding for components synthetic apparatus. These contain an oligopyrimidine tract at their 5' transcriptional start site, termed a 5'TOP, which shown to be essential level. In parallel, great deal information accumulated concerning identification regulatory sites involved controlling S6K activation. Despite this we are beginning identify direct upstream elements factor-induced Use immunosupressant rapamycin, bacterial macrolide, conjunction with dominant interfering activated forms S6K1 helped establish cascade addition, studies employing mouse as well Drosophila melanogaster have provided new insights into physiological function animal. Deletion gene cells led animal reduced size homolog, S6K2, whereas loss dS6K demonstrated its paramount importance development control.