Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors

摘要: Rapamycin and its analogs are versatile drugs with proven efficacy in cardiovascular transplant medicine promising results early cancer clinical trials. In specific tumor types, a select minority of patients likely will benefit from monotherapy. The challenge for the future be to dissect further molecular signaling pathways modulated by rapamycin order appreciate fully mechanisms underpinning sensitivity or resistance mTOR inhibition. This understanding provide insight into rational combinations inhibitors classic cytotoxic agents, radiation, other molecularly targeted therapies.