Deregulation of cell growth and malignant transformation.
作者： Ivan Dikić , Linda Panić , Sinisa Volarević , Sanda Sulić
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摘要: Cell growth and cell division are fundamental aspects of behavior in all organisms. Recent insights from many model organisms have shed light on the molecular mechanisms that control division. A significant body evidence has now been accumulated, showing a direct link between deregulation components cycle machinery cancer. In addition, defects one or more steps important for malignant transformation, as tumor suppressors proto-oncogenes found to regulate growth. The importance development is further supported by discovery rapamycin, an effective anticancer drug, inhibits key regulator protein synthetic growth, mammalian target rapamycin (mTOR). most cases, coupled, thereby maintaining size within physiological limits. We believe that, long-term perspective, understanding how these two processes coordinated vivo their interplay deregulated number diseases, including cancer, may impact efficiency modern therapeutics.
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