Structures mimicking sex cord‐stromal tumours and gonadoblastomas in the ovaries of normal infants and children

摘要: A chance finding of structures resembling gonadoblastomas in the ovaries a child with lissencephaly prompted detailed review all ovarian histology obtained at autopsy over 12 month period. Fifty-five stillbirths, infants and children were studied ranging from 20 weeks gestational age to 2.5 years post-natal age. In 19 mimicking sex cord tumours annular tubules seen. but one case these found association follicular cysts they closely resembled atretic follicles often seen stroma surrounding cysts. They differed only by virtue their being larger. addition, several Sertoli cell or clusters Leydig cells found. When present, always co-existed gonadoblastoma-like lesions. The abnormal stromal lesions most frequently stage development when massive 'physiological' reduction oocytes occurs. It is suggested that 'abnormal' identified this report represent 'first hit' oncogenesis could serve as precursor many cord-stromal tumours, possibly germ neoplasms, childhood.