Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing
作者： Andrew E. O. Hughes , Vincent Magrini , Ryan Demeter , Christopher A. Miller , Robert Fulton
DOI: 10.1371/JOURNAL.PGEN.1004462
关键词:
摘要: Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency individual clones, their genetic composition, and evolutionary relationships-which we set out test by cells from three subjects diagnosed with secondary acute myeloid leukemia, each whom had previously characterized whole genome unfractionated Single-cell mutation profiling strongly supported clonal architecture implied analysis bulk material. In addition, it resolved assignment single nucleotide variants that initially ambiguous identified areas unappreciated complexity. Accordingly, find many key assumptions underlying deep material are valid. Furthermore, illustrate a single-cell strategy for interrogating relationships among known is cost-effective, scalable, adaptable both hematopoietic solid tumors, or any cells.
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