Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish.
作者： Arunita Chatterjee , Debasish Roy , Esha Patnaik , Upendra Nongthomba
DOI: 10.1242/DMM.022665
关键词:
摘要: Muscle contraction brings about movement and locomotion in animals. However, muscles have also been implicated several atypical physiological processes including immune response. The role of immunity the mechanism involved has not yet deciphered. In this paper, using Drosophila indirect flight (IFMs) as a model, we show that are immune-responsive tissues. Flies with defective IFMs incapable mounting potent humoral Upon challenge, produce anti-microbial peptides (AMPs) through activation canonical signaling pathways, these IFM-synthesized AMPs essential for survival upon infection. trunk zebrafish, vertebrate model system, possess capacity to mount an response against bacterial infections, thus establishing responsiveness is evolutionarily conserved. Our results suggest physiologically fit might boost innate individual.
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