Transportation with very long transfer delays (> 90 min) for facilitated PCI with reduced-dose fibrinolysis in patients with ST-segment elevation myocardial infarction The Krakow Network

作者: Dariusz Dudek , Artur Dziewierz , Zbigniew Siudak , Tomasz Rakowski , Jaroslaw Zalewski

DOI: 10.1016/J.IJCARD.2008.10.020

关键词:

摘要: Abstract Background The majority of ST-segment elevation myocardial infarction (STEMI) patients are admitted to centers without primary percutaneous coronary intervention (PCI) facilities. Purpose the study was determine safety and outcomes in STEMI with transfer delay PCI>90 min receiving half-dose alteplase abciximab before PCI (facilitated reduced-dose fibrinolysis). Methods results Outcomes 669 ( 90 min who received full-dose were immediately transferred for compared effects 1311 P Conclusions This is first large report showing benefits transportation very long (>90 min) facilitated fibrinolysis patients. In fact, pharmacological treatment (combotherapy) effective overcoming deleterious time-delay on outcome, similar survival as short-time transportation, despite higher risk major bleeding complication.

参考文章(42)
Stephen G Ellis, Michal Tendera, Mark A de Belder, Ad J van Boven, Petr Widimsky, Luc Janssens, Henning Rud Andersen, Amadeo Betriu, Stefano Savonitto, Jerzy Adamus, Jan Z Peruga, Maciej Kosmider, Olivier Katz, Thomas Neunteufl, Julia Jorgova, Maria Dorobantu, Liliana Grinfeld, Paul Armstrong, Bruce R Brodie, Howard C Herrmann, Gilles Montalescot, Franz-Josef Neumann, Mark B Effron, Elliot S Barnathan, Eric J Topol, Facilitated PCI in patients with ST-elevation myocardial infarction. The New England Journal of Medicine. ,vol. 358, pp. 2205- 2217 ,(2008) , 10.1056/NEJMOA0706816
Bruce R. Brodie, Charles Hansen, Thomas D. Stuckey, Scott Richter, Debra S. VerSteeg, Navin Gupta, William E. Downey, Mark Pulsipher, Door-to-balloon time with primary percutaneous coronary intervention for acute myocardial infarction impacts late cardiac mortality in high-risk patients and patients presenting early after the onset of symptoms. Journal of the American College of Cardiology. ,vol. 47, pp. 289- 295 ,(2006) , 10.1016/J.JACC.2005.08.065
Bruno G, Muià N, Guiducci, Fioroni S, Navazio A, Gambarati G, Bendinelli S, Manari A, Giacometti P, Angioplasty in acute myocardial infarction after low-dose alteplase and abciximab in transferred patients. A comparison with primary angioplasty on site. Italian heart journal: official journal of the Italian Federation of Cardiology. ,vol. 4, pp. 311- ,(2003)
J Owen, KD Friedman, BA Grossman, C Wilkins, AD Berke, ER Powers, Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity Blood. ,vol. 72, pp. 616- 620 ,(1988) , 10.1182/BLOOD.V72.2.616.616
Bradley H. Strauss, Ian C. Gilchrist, Robert J. Chisholm, Kimberley A. Bowman, Luke D. Winegard, Mark E. Rea, Dharmesh Patel, Warren J. Cantor, Saleem Kassam, Radial versus femoral access for rescue percutaneous coronary intervention with adjuvant glycoprotein IIb/IIIa inhibitor use. Canadian Journal of Cardiology. ,vol. 20, pp. 1439- 1442 ,(2004)
Elliott M. Antman, Mary Hand, Paul W. Armstrong, Eric R. Bates, Lee A. Green, Lakshmi K. Halasyamani, Judith S. Hochman, Harlan M. Krumholz, Gervasio A. Lamas, Charles J. Mullany, David L. Pearle, Michael A. Sloan, Sidney C. Smith, Elliott M. Antman, Daniel T. Anbe, Paul W. Armstrong, Eric R. Bates, Lee A. Green, Mary Hand, Judith S. Hochman, Harlan M. Krumholz, Frederick G. Kushner, Gervasio A. Lamas, Charles J. Mullany, Joseph P. Ornato, David L. Pearle, Michael A. Sloan, Sidney C. Smith, Sidney C. Smith, Alice K. Jacobs, Cynthia D. Adams, Jeffrey L. Anderson, Christopher E. Buller, Mark A. Creager, Steven M. Ettinger, Jonathan L. Halperin, Sharon A. Hunt, Harlan M. Krumholz, Frederick G. Kushner, Bruce W. Lytle, Rick Nishimura, Richard L. Page, Barbara Riegel, Lynn G. Tarkington, Clyde W. Yancy, , 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. ,vol. 117, pp. 296- 329 ,(2008) , 10.1161/CIRCULATIONAHA.107.188209
Giuseppe Tarantini, Luisa Cacciavillani, Francesco Corbetti, Angelo Ramondo, Martina Perazzolo Marra, Enrico Bacchiega, Massimo Napodano, Claudio Bilato, Renato Razzolini, Sabino Iliceto, Duration of ischemia is a major determinant of transmurality and severe microvascular obstruction after primary angioplasty: a study performed with contrast-enhanced magnetic resonance. Journal of the American College of Cardiology. ,vol. 46, pp. 1229- 1235 ,(2005) , 10.1016/J.JACC.2005.06.054
Howard C Herrmann, David J Moliterno, E.Magnus Ohman, Amanda L Stebbins, Christopher Bode, Amadeo Betriu, Florian Forycki, Jerry S Miklin, William B Bachinsky, A.Michael Lincoff, Robert M Califf, Eric J Topol, Facilitation of early percutaneous coronary intervention after reteplase with or without abciximab in acute myocardial infarction: results from the SPEED (GUSTO-4 Pilot) Trial. Journal of the American College of Cardiology. ,vol. 36, pp. 1489- 1496 ,(2000) , 10.1016/S0735-1097(00)00923-2
Jean-Philippe Collet, Gilles Montalescot, Michel Le May, Maria Borentain, Anthony Gershlick, Percutaneous coronary intervention after fibrinolysis: a multiple meta-analyses approach according to the type of strategy Journal of the American College of Cardiology. ,vol. 48, pp. 1326- 1335 ,(2006) , 10.1016/J.JACC.2006.03.064