Pertuzumab – a HER-2 Dimerisation Inhibitor – for the Treatment of Breast and Other Cancers

作者: Giulia Bianchi , Luca Gianni

DOI: 10.1007/978-3-0346-0094-1_5

关键词:

摘要: Pertuzumab is a recombinant humanised monoclonal antibody targeting the extracellular domain of human epidermal growth factor receptor 2 (HER-2) to block HER-2 dimerisation with other HER family members. Preclinical pertuzumab data showed activity in number solid tumour types, and synergistic or additive was also observed when combined chemotherapy targeted agents, including trastuzumab erlotinib. has been studied clinical setting, both as monotherapy combination agents variety types. Following encouraging results Phase II trial patients HER-2-positive metastatic breast cancer, this indication become focus attention for further investigation.

参考文章(50)
Turner T, Wells A, Souto Jc, Kassis J, Kim Hg, EGF receptor signaling in prostate morphogenesis and tumorigenesis. Histology and Histopathology. ,vol. 14, pp. 1175- 1182 ,(1999) , 10.14670/HH-14.1175
R. Pinkas-Kramarski, L. Soussan, H. Waterman, G. Levkowitz, I. Alroy, L. Klapper, S. Lavi, R. Seger, B. J. Ratzkin, M. Sela, Y. Yarden, Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. The EMBO Journal. ,vol. 15, pp. 2452- 2467 ,(1996) , 10.1002/J.1460-2075.1996.TB00603.X
Yosef Yarden, Mark X. Sliwkowski, Untangling the ErbB signalling network Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 127- 137 ,(2001) , 10.1038/35052073
R.C. BAST, L. PUSZTAI, BILLIE-JO KERNS, J.A. MACDONALD, PATRICK JORDAN, LEE DALY, CINDA M. BOYER, JOHN MENDELSOHN, ANDREW BERCHUCK, Coexpression of the HER-2 gene product, p185HER-2, and epidermal growth factor receptor, p170EGF-R, on epithelial ovarian cancers and normal tissues. Hybridoma. ,vol. 17, pp. 313- 321 ,(1998) , 10.1089/HYB.1998.17.313
Manuela Campiglio, Suhad Ali, Piotr G. Knyazev, Axel Ullrich, Characteristics of EGFR family-mediated HRG signals in human ovarian cancer. Journal of Cellular Biochemistry. ,vol. 73, pp. 522- 532 ,(1999) , 10.1002/(SICI)1097-4644(19990615)73:4<522::AID-JCB10>3.0.CO;2-4
Camellia W. Adams, David E. Allison, Kelly Flagella, Leonard Presta, Janet Clarke, Noel Dybdal, Kathleen McKeever, Mark X. Sliwkowski, Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunology, Immunotherapy. ,vol. 55, pp. 717- 727 ,(2006) , 10.1007/S00262-005-0058-X
Christoph A Maurer, Helmut Friess, Bodo Kretschmann, Arthur Zimmermann, Anita Stauffer, Hans U Baer, Murray Korc, Markus W Buchler, Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2 Human Pathology. ,vol. 29, pp. 771- 777 ,(1998) , 10.1016/S0046-8177(98)90444-0