The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands.

作者: Eldad Tzahar , Yosef Yarden

DOI: 10.1016/S0304-419X(97)00032-2

关键词: Receptor tyrosine kinaseChemistryPlatelet-derived growth factor receptorNeuregulinGrowth factor receptorInsulin-like growth factor 1 receptorErbBROR1Signal transductionCancer research

摘要: Extensive clinical and biochemical evidence implicates ErbB-2, a transmembrane tyrosine kinase related to growth factor receptors, in the development, metastasis, and resistance to …

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