Increased Antioxidant Resistant Cells Enzyme Activity in Amyloid Protein

摘要: Clones of the rat pheochromocytoma cell line PC1 2 were selected for their resistance to amyloid p protein (A/3). These A/3-resistant cells also survive higher concentrations exogenously applied peroxides than parent cells. AP triggers intracellular H,O, accumulation in PC12 but not AP-resistant The absence A/+resistant is attributable differences binding surface. However, mRNA and levels catalase glutathione peroxidase, as well corresponding enzyme activities, are highly elevated clones. activities correlate with increased A/3 or peroxides. Finally, transfected peroxidase more resistant toxicity. results indicate that antioxidant account at least pat-t substantiate further role