The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer
作者： Leo Y. Luo , Eejung Kim , Hiu Wing Cheung , Barbara A. Weir , Gavin P. Dunn
DOI: 10.1158/1541-7786.MCR-14-0407
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摘要: High-grade serous ovarian cancers (HGSOC) are characterized by widespread recurrent regions of copy-number gain and loss. Here, we interrogated 50 genes that recurrently amplified in HGSOC essential for cancer proliferation survival cell lines. FRS2 is one the located on chromosomal region 12q15 focally 12.5% HGSOC. We found -amplified lines dependent expression, overexpression immortalized human conferred ability to grow an anchorage-independent manner as tumors immunodeficient mice. FRS2, adaptor protein FGFR pathway, induces downstream activation Ras–MAPK pathway. These observations identify oncogene a subset harbor amplifications. Implications: studies expression cells amplification. Mol Cancer Res; 13(3); 502–9. ©2014 AACR . This article featured Highlights This Issue, [p. 391][1] [1]: /lookup/volpage/13/391?iss=3
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