The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis
作者： Marleen van Gramberen , Stefano Fracchioli , Andreas Scorilas , Marco Massobrio , Ulf-Hakan Stenman
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摘要: Human kallikrein 10 (hK10) is a secreted serine protease that highly expressed in ovarian tissue. We hypothesized hK10 might represent novel serological marker for cancer. quantified by immunoassay, sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 146 then examined the diagnostic prognostic value of this measurement found serum ranged 50 to 1040 ng/liter (mean = 439 ng/liter). concentration significantly elevated presurgical cancer (range: 106-11,746 ng/liter; mean 1067 ng/liter) but not diseases 120-1200 447 When cutoff 700 was selected (diagnostic specificity 90%), sensitivity 54%. About 35% CA125-negative (CA125 1 cm), suboptimal debulking, no response chemotherapy (all Ps < 0.001). In univariate Cox survival analysis, high associated increased risk relapse death (hazard ratio 2.59 3.15, respectively, P
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