CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions
作者： Valerie Dardalhon , Anna S Schubart , Jayagopala Reddy , Jennifer Hartt Meyers , Laurent Monney
DOI: 10.4049/JIMMUNOL.175.3.1558
关键词:
摘要: Surface molecules that are differentially expressed on Th1 and Th2 cells may be useful in regulating specific immune responses vivo. Using a panel of mAbs, we have identified murine CD226 as specifically the surface differentiated but not or Th0 cells. Although is constitutively CD8 cells, it up-regulated CD4 upon activation. differentiation results enhanced expression, whereas expression down-regulated polarization. We demonstrate involved regulation T cell activation; vivo treatment with anti-CD226 significant reduction expansion induction APCs inhibit Furthermore, delays onset reduces severity Th1-mediated autoimmune disease, experimental encephalomyelitis. Our data suggest costimulatory molecule plays an important role activation effector functions
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